I'm frequently asked what I consider"anti-wrinkle" products, most importantly, those that contain retinoids, which are vitamin A derivatives that claim that the"Fountain of Youth" in a jar. The response I give to patients is never a hot one and almost never the response the consumer would like to hear. I base this response on three matters: Scientific literature; Thirty years of expertise as a board-certified dermatologist and; for a consumer who has tried most topical retinoid creams for extended periods of time