Correlation between Abdominal Circumference and Serum High-Sensitivity C-Reactive Protein Concentration at Age 35–64 Years

Nabila Damayanti, Eveline Margo


The prevalence of central obesity in Indonesia is increasing every year. Based on data released by Riskesdas in 2018, there were 31% of the population aged 15 years and over suffer from central obesity, where the highest was found in the 45–54 years group (42.3%), followed by 44 years (39.2%) and 55–64 years group (39.1%). Central obesity can be measured by waist circumference or abdominal circumference, and it plays an important role in the occurrence of cardiovascular disease. Examining C-reactive protein (CRP) at low levels using high-sensitivity CRP (hs-CRP) methods will help to predict the risk of coronary heart disease. This study aimed to find the correlation between waist circumference and hs-CRP serum levels between the ages of 35 and 64. The study was an analytical observational with a cross-sectional approach attended by 25 respondents at Bhayangkara Hospital Tingkat I Raden Said Sukanto, Kramat Jati, East Jakarta, from October to November 2019. The waist circumference was measured with a metlin roll, and Prodia Laboratory took the blood to measure hs-CRP serum levels using ELISA methods. The data were analyzed using the Pearson correlation test. The results showed a correlation between waist circumference and hs-CRP serum levels with Sig. (2-tailed)=0.000 (p<0.05). There was a correlation between waist circumference and hs-CRP serum levels, which indicated that the greater the waist circumference, the higher levels of serum hsCRP would be.


Abdominal circumference; central obesity; hs-CRP

Full Text:



Septiyanti, Seniwati. Obesitas dan obesitas sentral pada masyrakat usia dewasa di daerah perkotaan Indonesia. JIKA. 2020;2(3):118–27.

World Health Organization. Waist circumference and waist-hip ratio: report of a WHO expert consultation. Geneva: World Health Organization; 2011.

Ahmad A, Adam SIM, Nawi AM, Hassan MR, Ghazi HF. Abdominal obesity indicators: waist circumference or waist-to-hip ratio in Malaysian adults population. Int J Prev Med. 2016;7:82.

Ashwell M, Gibson S. Waist-to-height ratio as an indicator of ‘early health risk’: simpler and more predictive than using a ‘matrix’ based on BMI and waist circumferences. BMJ Open. 2016;6(3):e010159.

Sofa IM. Kejadian obesitas, obesitas sentral, dan kelebihan lemak viseral pada lansia wanita. Amerta Nutr. 2018;2(3):228–36.

Chen Y, Kassam I, Lau SH, Kooner JS, Wilson R, Peters A, et al. Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals. Clin Epigenetics. 2021;13(1):195.

Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan Republik Indonesia. Laporan Nasional Riskesdas 2018. Jakarta: Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan; 2019.

Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan Republik Indonesia. Riset kesehatan dasar (Riskesdas 2013) [Internet]. Jakarta: Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan Republik Indonesia; 2013 [cited 2019 April 25]. Available from:

American Heart Association. Cardiovascular disease: a costly burden for America [Internet]. Washington, DC: American Heart Association; 2017 [cited 2019 April 30]. Available from:

Kementerian Kesehatan Republik Indonesia. Tekan angka kematian melalui program indonesia sehat dengan pendekatan keluarga [Internet]. Jakarta: Kementerian Kesehatan Republik Indonesia; 2017 [cited 2019 May 1]. Available from:

Habib SS, Al Masri AA. Relationship of high sensitivity C-reactive protein with presence and severity of coronary artery disease. Pak J Med Sci. 2013;29(6):1425–9.

Bennett NR, Ferguson TS, Bennett FI, Tulloch-Reid MK, Younger-Coleman NOM, Jackson MD, et al. High-sensitivity C-reactive protein is related to central obesity and the number of metabolic syndrome components in Jamaican young adults. Front Cardiovasc Med. 2014;1:12.

Kollathody S, Venmadatheyil AJ, Puthanveettil M, Warrier PK. Association of hs-CRP with various components of metabolic syndrome. IJHRS. 2016;5(2):71–8.

Veghari G, Sedaghat M, Banihashem S, Moharloei P, Angizeh A, Tazik E, et al. Trends in waist circumference and central obesity in adults, Northern Iran. Oman Med J. 2012;27(1):50–3.

Wahyuni N, Murbawani EA. Hubungan lingkar pinggang dan rasio lingkar pinggang panggul dengan kadar serum high sensitivity C-reactive protein (hsCRP) pada remaja obesitas. J Nutr Coll. 2016;5(4):388–92.

Macek P, Biskup M, Terek-Derszniak M, Stachura M, Krol H, Gozdz S, et al. Optimal body fat percentage cut-off values in predicting the obesity-related cardiovascular risk factors: a cross-sectional cohort study. Diabetes Metab Syndr Obes. 2020;13:1587–97.

Islam MR, Moinuddin M, Saqib SM, Rahman SM. Relationship of anthropometric indicators of general and abdominal obesity with hypertension and their predictive performance among Albanians: a nationwide cross-sectional study. Nutrients. 2021;25(10):3373.

Guyenet SJ, Schwartz MW. Regulation of food intake, energy balance, and body fat mass: Implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab. 2012;97(3):745–55.

Proborini AS, Sulchan M, Dieny FF. Kadar C-reactive protein pada remaja stunted obesity usia 12–17 tahun di Kota Semarang. J Nutr Coll. 2017;6(2):198–203.

Landecho MF, Tuero C, Valentí V, Bilbao I, de la Higuera M, Frühbeck G. Relevance of leptin and other adipokines in obesity-associated cardiovascular risk. Nutrients. 2019;11(11):2664.

Djunet NA, Rissa F. Korelasi lingkar pinggang dengan kadar high sensitivity C-reactive protein serum pada mahasiswa kedokteran Universitas Muhammadiyah Jakarta. J Kedokteran Kesehat. 2016;12(2):129–36.


pISSN 2301-9123 | eISSN 2460-5441

Visitor since 19 October 2016: 

View My Stats

Free counters!

Global Medical and Health Communication is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.