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Scoping Review: Peran Platelet-Rich Fibrin (PRF) dalam Terapi Regeneratif Peri-Implantitis
Abstract
Abstrak
Peri-implantitis adalah peradangan yang mengakibatkan defek tulang di sekitar implan. Penatalaksanaan bedah peri-implantitis dimaksudkan untuk menghilangkan poket peri-implan patologis atau bahkan defek tulang yang beregenerasi. Platelet-rich fibrin (PRF) adalah biomaterial yang diperoleh dari darah manusia, terdiri dari konsentrat trombosit, matriks fibrin, sitokin, growth factors, dan sel. Karena potensi regeneratifnya, PRF mungkin berguna untuk meregenerasi defek tulang di sekitar implan. Studi ini bertujuan mengetahui penggunaan PRF dalam terapi bedah peri-implantitis. Metode scoping review dilakukan dengan menganalisis artikel yang diterbitkan dari tahun 2013–2023 sesuai dengan pedoman PRISMA. Pencarian dilakukan dengan google scholar. Hasil terdapat tiga artikel uji klinis yang disertakan pada studi ini tentang penggunaan PRF dalam terapi bedah regeneratif peri-implantitis. Simpulan karena PRF mengandung berbagai jenis growth factor, PRF dapat mempercepat proses penyembuhan awal dan meningkatkan regenerasi defek tulang pada peri-implantitis.
Role of Platelet-Rich Fibrin (PRF) in Peri-Implantitis Regenerative Therapy
Abstract
Peri-implantitis is an inflammation that results in bone loss surrounding an implant. Surgical management of peri-implantitis is intended to eliminate pathological peri-implant pockets or even regenerate bone defects. Platelet-rich fibrin (PRF) is a human blood biomaterial consisting of platelet concentrate, fibrin matrix, cytokines, growth factors, and cells. Due to its regenerative potential, PRF may be useful in regenerating bone defects around the implant. This scoping review aims to describe the usage of PRF in peri-implantitis regenerative therapy. A scoping review method was conducted by analyzing published articles from 2013–2023 according to PRISMA guidelines. The search was carried out using Google Scholar. Three clinical trials were included in this review discussing the use of PRF in regenerative peri-implantitis therapy. Conclusion: PRF enhances the mid-term recovery process and bone regeneration in peri-implantitis due to its variation growth factor components.
Keywords
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Rokaya D, Srimaneepong V, Wisitrasameewon W, Humagain M, Thunyakitpisal P. Peri-implantitis update: risk indicators, diagnosis, and treatment. Eur J Dent. 2020 Oct 3;14(04):672–82.
Smeets R, Henningsen A, Jung O, Heiland M, Hammächer C, Stein JM. Definition, etiology, prevention and treatment of peri-implantitis–a review. Head Face Med. 2014 Dec 3;10(1):34.
Chiapasco M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants. 2009;24 Suppl:237–59.
Sculean A, Nikolidakis D, Schwarz F. Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials–biological foundation and preclinical evidence: a systematic review. J Clin Periodontol. 2008 Sep;35(8 Suppl):106–16.
Clipet F, Tricot S, Alno N, Massot M, Solhi H, Cathelineau G, dkk. In vitro effects of choukroun’s platelet-rich fibrin conditioned medium on 3 different cell lines implicated in dental implantology. Implant Dent. 2012 Feb;21(1):51–6.
Hamzacebi B, Oduncuoglu B, Alaaddinoglu E. Treatment of peri-implant bone defects with platelet-rich fibrin. Int J Periodontics Restorative Dent. 2015 May;35(3):415–22.
Thorat M, Pradeep AR, Pallavi B. Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial. J Clin Periodontol. 2011 Oct;38(10):925–32.
Heitz-Mayfield LJA, Salvi GE, Mombelli A, Faddy M, Lang NP. Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study. Clin Oral Implants Res. 2012 Feb;23(2):205–10.
Sharma A, Pradeep AR. Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet-rich fibrin: a randomized controlled clinical trial. J Periodontol. 2011 Dec;82(12):1705–12.
Del Corso M, Vervelle A, Simonpieri A, Jimbo R, Inchingolo F, Sammartino G, dkk. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: periodontal and dentoalveolar surgery. Curr Pharm Biotechnol. 2012 May 1;13(7):1207–30.
Sheikh Z, Qureshi J, Alshahrani AM, Nassar H, Ikeda Y, Glogauer M, dkk. Collagen based barrier membranes for periodontal guided bone regeneration applications. Odontology. 2017 Jan;105(1):1–12.
Miron RJ, Zucchelli G, Pikos MA, Salama M, Lee S, Guillemette V, dkk. Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clin Oral Investig. 2017 Jul;21(6):1913–27.
Isobe K, Watanebe T, Kawabata H, Kitamura Y, Okudera T, Okudera H, dkk. Mechanical and degradation properties of advanced platelet-rich fibrin (A-PRF), concentrated growth factors (CGF), and platelet-poor plasma-derived fibrin (PPTF). Int J Implant Dent. 2017 Dec;3(1):17.
Lee JW, Kim SG, Kim JY, Lee YC, Choi JY, Dragos R, dkk. Restoration of a peri-implant defect by platelet-rich fibrin. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Apr;113(4):459–63.
Şimşek S, Özeç İ, Kürkçü M, Benlidayı E. Histomorphometric evaluation of bone formation in peri-implant defects treated with different regeneration techniques: an experimental study in a rabbit model. J Oral Maxillofac Surg. 2016 Sep;74(9):1757–64.
Matarasso S, Iorio Siciliano V, Aglietta M, Andreuccetti G, Salvi GE. Clinical and radiographic outcomes of a combined resective and regenerative approach in the treatment of peri-implantitis: a prospective case series. Clin Oral Implants Res. 2014 Jul;25(7):761–7.
Gassling V, Purcz N, Braesen JH, Will M, Gierloff M, Behrens E, dkk. Comparison of two different absorbable membranes for the coverage of lateral osteotomy sites in maxillary sinus augmentation: a preliminary study. J Craniomaxillofac Surg. 2013 Jan;41(1):76–82.
DOI: https://doi.org/10.29313/jiks.v5i2.11947
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