Efek Antidislipidemia Fraksi Jahe Gajah pada Mencit Model Sindrom Metabolik

Abstract

Sindrom metabolik merupakan istilah yang menggambarkan keadaan kombinasi klinis, yaitu hipertensi, hiperglikemia, dislipidemia, dan obesitas. Dislipidemia adalah keadaan metabolisme lipid pada tubuh terganggu. Kandungan flavonoid dalam jahe gajah dapat memengaruhi profil lipid dalam tubuh. Tujuan penelitian ini menganalisis pengaruh fraksi etil asetat jahe gajah terhadap kadar HDL dan LDL pada mencit model sindrom metabolik. Penelitian ini adalah penelitian eksperimental laboratorik dengan 20 ekor mencit jantan tua (36–40 minggu) Penelitian dilaksanakan di Laboratorium Farmasi Institut Teknologi Bandung (ITB) dan Laboratorium Patologi Klinik RSUD Cicalengka. bulan Maret-Mei 2019. Mencit dibagi menjadi 4 kelompok. Semua kelompok diberikan pakan tinggi lemak selama 28 hari. Kelompok kontrol tanpa diberi fraksi jahe, kelompok perlakuan 1 fraksi etil asetat jahe gajah 0,78 mg/kg bobot/hari, kelompok perlakuan 2 diberikan fraksi etil asetat jahe gajah 1,56 mg/kg bobot/hari, dan kelompok perlakuan 3 diberikan fraksi etil asetat jahe gajah 3,12 mg/kg bobot/hari. Rerata kadar HDL kelompok perlakuan cenderung meningkat, sedangkan rerata kadar LDL kelompok perlakuan ada kecenderungan menurun. Analisis statistik dengan one-way ANOVA, baik kadar HDL dan LDL menunjukkan hasil tidak signifikan (p HDL=0,190) dan (p LDL=0,300). Koefisien korelasi dengan Uji Pearson konsentrasi fraksi jahe gajah dengan kadar HDL dan LDL memiliki hubungan yang rendah, tetapi pasti (r=0,23). Simpulan, fraksi etil asetat jahe gajah memengaruhi kadar HDL dan LDL.

ANTI DYSLIPIDEMIA EFFECT OF GINGER FRACTION IN METABOLIC SYNDROME MICE MODELS

Metabolic syndrome is a term that describes the clinical combination of hypertension, hyperglycemia, dyslipidemia and obesity. Dyslipidemia is a state of disruption of lipid metabolism in the body. The flavonoids in elephant ginger can affect the lipid profile in the body. The purpose of this study was to analyze the effect of ginger elephant ethyl acetate fraction on HDL and LDL levels in metabolic syndrome mice models. Laboratory experimental study with 20 old male mice (36–40 weeks) The study was held in Laboratorium Farmasi Institut Teknologi Bandung (ITB) and Laboratorium Patologi Klinik RSUD Cicalengka. during March-May 2019. Mice are divided into 4 groups. All groups were fed a high-fat diet for 28 days. The control group was given no ginger fraction, group 1 was given elephant glycol ethyl acetate 0.78 mg/kgBW/day, treatment group 2 was given elephant glycol ethyl acetate 1.56 mg/kgBW/day, and treatment group 3 was given elephant ginger ethyl acetate fraction 3.12 mg/kgBW/day. The mean HDL level of the treatment group tended to increase, while the mean LDL level of the treatment group there was a downward. Statistical analysis with one-way ANOVA, both HDL and LDL levels showed insignificant results (HDL p value=0.190) and (LDL p value=0.300). The correlation between the concentration of ginger elephant fraction on HDL and LDL levels with Pearson showed small results (r=0.23). In conclusion, the ginger elephant ethyl acetate fraction affected HDL and LDL levels.