Pengaruh Paparan Asap Rokok Tersier terhadap Kadar Kolesterol Total dan Trigliserida Mencit

Putra Zam Zam Rachmatullah, Samsudin Surialaga, Annisa Rahmah Furqaani

Abstract


Jumlah perokok aktif saat ini semakin meningkat sehingga perokok pasif dan residu yang tersisa atau paparan asap tersier juga meningkat. Salah satu dampak buruk rokok dapat menyebabkan dislipidemia, di antaranya peningkatan kadar kolesterol total dan trigliserida. Tujuan penelitian adalah menganalisis pengaruh paparan asap rokok tersier terhadap kadar kolesterol total dan trigliserida. Penelitian ini merupakan eksperimental in vivo dengan subjek penelitian mencit yang dibagi menjadi dua kelompok, yaitu kelompok kontrol yang tidak diberikan perlakuan dan kelompok perlakuan yang diberikan paparan asap rokok tersier selama 29 hari. Penelitian dilakukan di Laboratorium Hewan FK Unisba selama bulan Maret–April 2009. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan kadar kolesterol dan trigliserida antara kelompok kontrol dan kelompok perlakuan (p>0,05). Hasil ini mengindikasikan bahwa paparan asap rokok tersier belum memengaruhi kadar kolesterol total dan trigliserida. Durasi paparan asap rokok akut dengan intensitas ringan yang diberikan pada penelitian ini diduga belum memengaruhi metabolisme lipid.

 

EFFECT OF THIRDHAND SMOKE EXPOSURE ON TOTAL CHOLESTEROL AND TRIGLYCERIDE LEVEL IN MICE

Nowadays, an increase in the number of active smokers also indicates an increase in passive smokers and residual smoke or thirdhand smoke exposure. One of the impact of cigarette is dyslipidemia, characterized by elevation level of total cholesterol and triglycerides. The objective of the study was to analyze the effect of thirdhand smoke exposure on the level of total cholesterol and triglycerides. This study used an in vivo experimental design with one cigarette a day and 20 mice as the subject. The subjects divided into 2 groups, the control group received no treatment and the treatment group received thirdhand smoke exposure for 29 days. The study was conducted of Laboratorium Hewan FK Unisba during March–April 2009. The result of the study showed there was no significant difference in the level of total cholesterol and triglycerides among the control group and the treatment group (p>0.05). The result indicated that thirdhand smoke exposure had no effect on the level of total cholesterol and triglycerides. The duration of acute cigarette smoke exposure with low intensity given in this study suspected to not affect the lipid metabolism.


Keywords


Asap rokok tersier; kadar kolesterol total; kadar trigliserida; Thirdhand smoke; total cholesterol level; triglycerides level

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DOI: https://doi.org/10.29313/jiks.v2i2.5847

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