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Scoping Review: Efek Nefroprotektif Black Garlic/Aged Garlic pada Hewan Model Renal Injury
Abstract
Kerusakan ginjal atau renal injury didefinisikan sebagai penurunan fungsi ginjal yang meliputi cedera (kerusakan struktural) dan gangguan (hilangnya fungsi) ginjal. Salah satu bentuk antioksidan yang digunakan sebagai pengobatan kerusakan ginjal adalah sediaan black garlic yang merupakan bawang putih (Allium sativum L.) yang telah difermentasi dan memiliki banyak antioksidan poten. Penelitian ini bertujuan menganalisis pengaruh black garlic/aged garlic terhadap kerusakan ginjal pada hewan coba model renal injury. Metode pada penelitian ini adalah Scoping Review. Pencarian sistematis dari beberapa database, yaitu SpringerLink, ScienceDirect, ProQuest, EBSCO dan Google Scholar. Artikel yang sesuai dengan kriteria inklusi sebanyak 2.259 dan yang memenuhi kriteria ekslusi berdasar atas kriteria PICOS yang dilakukan oleh 2 peneliti, didapatkan hasil 14 artikel. Penelitian ini dilakukan selama periode Maret–Desember 2020 Hasil analisis serta identifikasi dari 14 artikel, keseluruhan artikel menunjukkan pengaruh positif black garlic/aged garlic pada ginjal hewan coba. Dari 14 artikel, ditemukan perbaikan mikrostruktur ginjal, fungsi ginjal meningkat, peningkatan kadar antioksidan pada ginjal, penurunan marker stres oksidatif serta penurunan mediator inflamasi. Kesimpulan analisis pada penelitian ini adalah black garlic/aged garlic memiliki sifat nefroprotektif yang melindungi ginjal dari kerusakan yang disebabkan oleh stres oksidatif.
Nephroprotective Effects of Black Garlic/Aged Garlic on Animal Model of Renal Injury: a Scoping Review
Kidney damage or renal injury is defined as decreased function of the kidneys, which includes both injury (structural damage) and impairment (loss of function) of the kidneys. One form of antioxidant that is used to treat kidney damage is black garlic, which isgarlic (Allium sativum L.fermented) and has many potent antioxidants. This study aims to analyze the effect of black garlic/aged garlic on kidney damage in animal models of renal injury. The method in this research is the Scoping Review. Systematic search of several databases, namely SpringerLink, ScienceDirect, ProQuest, EBSCO and Google Scholar. There were 2,259 articles that matched the inclusion criteria and those that met the exclusion criteria based on the PICOS criteria conducted by 2 researchers, the results were 14 articles. This research was conducted during the period March–December 2020. The results of the analysis and identification of 14 articles, all of them showed the positive effect of black garlic/aged garlic on the kidneys of experimental animals. From 14 articles, it was found that there was an improvement in renal microstructure, increased renal function, an increase in antioxidant levels in the kidney, a decrease in markers oxidative stressand a decrease in inflammatory mediators. The conclusion from the analysis in this study is that black garlic/aged garlic has nephroprotective properties that protect the kidneys from damage caused by oxidative stress.
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Kemenkes RI. Riset Kesehatan Dasar 2013 [Internet]. Riset Kesehatan Dasar. Jakarta, Indonesia; 2013. [diunduh December 30, 2020] Tersedia dari: https://www.kemkes.go.id/resources/download/general/Hasil Riskesdas 2013.pdf
World Health Organization [WHO]. Global Action Plan For The Prevention And Control of Noncommunicable Diseases [Internet]. Revista Brasileira de Enfermagem. Aug. [diunduh December 30, 2020] Tersedia dari: https://www.who.int/nmh/publications/ncd-action-plan/en/
Kemenkes RI. Laporan Nasional Hasil Riset Kesehatan Dasar (Riskesdas) Indonesia tahun 2018. Riset Kesehatan Dasar 2018. 2018. p. 166.
Ozbek E. Induction of oxidative stress in kidney. Int J Nephrol. 2012;2012.
Ratliff BB, Abdulmahdi W, Pawar R, Wolin MS. Oxidant Mechanisms in Renal Injury and Disease. Antioxidants Redox Signal. 2016;25(3):119–46.
Harrison I of MP. Harrison’s Principles of Internal Medicine. Harrison’s Princ Intern Med. 2015;1716.
Li H Di, Meng XM, Huang C, Zhang L, Lv XW, Li J. Application of herbal traditional Chinese medicine in the treatment of acute kidney injury. Front Pharmacol. 2019;10(MAR):1–12.
Ranasasmita R. Kehalalan Produk Obat-Obatan ,. Pros Simp Penelit Bahan Obat Alami XIV. 2011;(Taylor 2001):552–9.
Rahimah SB, Kharisma Y, Nurhayati E, Yuniarti Y, Santoso SD, Faridza M. Community Knowledge and Behavior in the Utilization of Medicinal Plants in Cikoneng Village Bandung District. Glob Med Heal Commun. 2019;7(1):15–20.
Kimura S, Tung YC, Pan MH, Su NW, Lai YJ, Cheng KC. Black garlic: A critical review of its production, bioactivity, and application. J Food Drug Anal [diunduh December 30, 2020] [Internet]. 2017;25(1):62–70. Tersedia dari: http://dx.doi.org/10.1016/j.jfda.2016.11.003
Czompa A, Szoke K, Prokisch J, Gyongyosi A, Bak I, Balla G, et al. Aged (Black) versus raw garlic against ischemia/reperfusion-induced cardiac complications. Int J Mol Sci. 2018;19(4):1–14.
Shin J-Y, Han J-H, Ko J-W, Park S-H, Shin N-R, Jung T-Y, et al. Diallyl disulfide attenuates acetaminophen-induced renal injury in rats. Lab Anim Res. 2016;32(4):200.
Lee TW, Bae E, Kim JH, Jang HN, Cho HS, Chang SH, et al. The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats. Ren Fail [Internet]. 2019;41(1):24–33. [diunduh December 30, 2020] Tersedia dari: https://doi.org/10.1080/0886022X.2018.1561375
Zhu X, Jiang X, Li A, Zhao Z, Li S. S‐allylmercaptocysteine attenuates cisplatin‐induced nephrotoxicity through suppression of apoptosis, oxidative stress, and inflammation. Nutrients. 2017;9(2).
Nasr AY, Saleh HAM. Aged garlic extract protects against oxidative stress and renal changes in cisplatin-treated adult male rats. Cancer Cell Int. 2014;14(1):1–12.
Shiju TM, Rajesh NG, Viswanathan P. Renoprotective effect of aged garlic extract in streptozotocin-induced diabetic rats. Indian J Pharmacol. 2013;45(1):18–23.
Khajevand-Khazaei MR, Azimi S, Sedighnejad L, Salari S, Ghorbanpour A, Baluchnejadmojarad T, et al. S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation. Int Immunopharmacol [Internet]. 2019;69(February 2018):19–26. [diunduh December 30, 2020] Tersedia dari: https://doi.org/10.1016/j.intimp.2019.01.026
Albrakati A. Aged garlic extract rescues ethephon-induced kidney damage by modulating oxidative stress, apoptosis, inflammation, and histopathological changes in rats. Environ Sci Pollut Res. 2020;
Youssef NA, Al Shalat IA. Aged garlic extract ameliorates the oxidative stress, histomorphological, and ultrastructural changes of cisplatin-induced nephrotoxicity in adult male rats. Microsc Res Tech. 2015;78(6):452–61.
Prihanti GS, Faradilla A, Rahman M. The effect of single type black garlic (Allium sativum L.) extract on the cell of langerhans islets and the kidney tubular microscopy in male wistar rats (rattus norvegicus) models of diabetes mellitus. Syst Rev Pharm. 2020;11(6):290–6.
El-Beih NM, Ramadan G, Khorshed MA, Ahmed RSA. Biochemical alterations in insecticides-treated male albino rats: Potential modulatory effects of a standardized aged garlic extract. Indian J Tradit Knowl. 2017;16(2):181–8.
Foubi BBK, Djamen DPC, Djomeni PDD, Nganou OS, Myriam AM, Fotsin JG. Protective effects of aged garlic extract against oxidative stress induced by total body irradiation in albino Wistar rat’s kidney. J Chem J Chem Bio Phy Sci Sec B J Chem Bio Phy Sci Sec B. 2016;777(111):100–13.
Foubi BBK, Djamen DPC, Djomeni PDD, Foubi MAM, Ngano OS, Sone M, et al. Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats. Nucl Med [Internet]. 2016;1(1):1–21. [diunduh December 30, 2020] Tersedia dari: http://www.sciencepublishinggroup.com/j/nm
Thomson M, Al-Qattan KK, Divya JS, Ali M. Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats. BMC Complement Altern Med [Internet]. 2016;16(1):1–9. [diunduh December 30, 2020] Tersedia dari: http://dx.doi.org/10.1186/s12906-016-0992-5
Thomson M, Al-Qattan K, Jayasree D, Ali M. Oral intake of aged garlic extract (AGE) ameliorates oxidative stress and other streptozotocin-induced diabetic complications in rats. Int J Pharmacol. 2017;13(6):593–602.
DOI: https://doi.org/10.29313/jiks.v3i1.7430
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