Scoping Review: Rasio Monosit Limfosit sebagai Penunjang untuk Menegakkan Diagnosis pada Penderita Tuberkulosis

Algifari Fauzia, Purwitasari Purwitasari, Heni Muflihah

Abstract


Tuberkulosis (TB) merupakan penyakit yang disebabkan oleh Mycobacterium tuberculosis. Indonesia menempati urutan ketiga kasus TB terbanyak di dunia. Pemeriksaan bakteriologis menjadi standar untuk menegakkan diagnosis tuberkulosis. Keterbatasan pemeriksaan kultur bakteri adalah membutuhkan waktu yang lama, sedangkan pemeriksaan TCM tidak selalu menunjukkan bakteri masih hidup. Pemeriksaan imunologis interferon-γ release assays (IGRA) memiliki harga mahal dan membutuhkan alat khusus. Pemeriksaan hematologi rutin mudah dilakukan sehingga memiliki potensi menunjang penegakan diagnosis TB berdasar atas parameter imunologis. Tujuan penelitian ini adalah melakukan literature review untuk mengidentifikasi potensi rasio monosit limfosit (MLR) sebagai penunjang diagnosis TB. Pencarian artikel dilakukan secara online dari database Pubmed, Springer Link, dan Science Direct. Tahapan penyaringan artikel mengikuti alur PRISMA. Pada tahap akhir, artikel yang eligible dipilih berdasar atas kriteria patient, intervention, comparison, outcome, and study (PICOS), yaitu pasien TB, rasio monosit limfosit, diagnosis TB, dan original study. Hasil penelitian ini mendapatkan tujuh artikel dari jumlah awal 8.942 artikel yang ditemukan dari kata kunci. Dua dari tujuh artikel menyatakan MLR dapat menunjang diagnosis TB. Dua artikel menunjukkan monosit dan limfosit dapat menjadi penanda infeksi bakteri termasuk TB. Satu artikel menyatakan hubungan TB dengan penurunan produksi sitokin monosit dan limfosit. Dua artikel menyatakan MLR tidak ada hubungan dengan kasus TB. Terdapat satu artikel yang menyatakan batas nilai MLR 0,378 untuk menunjang diagnosis TB. Penelitian observasional tentang MLR untuk menunjang diagnosis TB di Indonesia masih perlu dilakukan terutama pengkajian batas nilai MLR.

 

SCOPING REVIEW: MONOCYTE LYMPHOCYTE RATIO AS SUPPORT TO ENFORCE ON PATIENT TUBERCULOSIS

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Indonesia ranks third with the most TB cases in the world. A bacteriological examination is a standard for diagnosing TB. A bacteriological examination is a standard for establishing the diagnosis of tuberculosis. The limitation of bacterial culture examination is that it takes a long time, while TCM examination does not always show the bacteria are still alive. Interferon-γ release assays (IGRA) examinations are expensive and require special equipment. Routine hematology tests are easy to do so as they have the potential to support the diagnosis of TB based on immunological parameters. The purpose of this study was to conduct a literature review to identify the potential for monocyte lymphocyte ratio (MLR) to support the diagnosis of TB. Search for articles was conducted online from PubMed, Springer Link, and Science Direct databases. The steps of filtering articles follow the PRISMA flow. In the final stage, eligible articles were selected based on patient, intervention, comparison, outcome, and study (PICOS) criteria, namely TB patient, monocyte lymphocyte ratio, TB diagnosis, and the original research. The results of this study obtained seven articles from 8,942 articles found from keywords. Two of the seven articles said that MLR could support the diagnosis of TB. Two articles showed that monocytes and lymphocytes could be markers of bacterial infection include TB. One article said the association of TB with decreased production of monocyte and lymphocyte cytokines. Two articles said that MLR had no relationship with TB cases. There is one article that states the MLR value limit is 0.378 to support the diagnosis of TB. Observational research on MLR to support the diagnosis of TB in Indonesia still needs to be done, especially the assessment of the limit of the MLR value.


Keywords


Diagnosis; hematologi; hematology; limfosit; lymphocyte; monocyte; monosit; tuberculosis; tuberkulosis

Full Text:

PDF

References


Husain AN. Lung. Dalam: Kumar V, Abbas AK, Aster JC, penyunting. Robbins basic pathology. Edisi ke-10. Philadelphia: Elsevier; 2017. p. 459–516.

World Health Organization. Global tuberculosis report 2019. Geneva: World Health Organization; 2019.

Sibley L, Gooch K, Wareham A, Gray S, Chancellor A, Dowall S, dkk. Differences in monocyte: lymphocyte ratio and tuberculosis disease progression in genetically distinct populations of macaques. Sci Rep. 2019;9(1):3340.

Rees CA, Pineros DB, Amour M, Munseri P, Said J, Magohe A, dkk. The potential of CBC-derived ratios (monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte) to predict or diagnose incident TB infection in Tanzanian adolescents. BMC Infect Dis. 2020;20(1):609.

Choudhary R, Wall K, Njuguna I, Pavlinac P, Lacourse S, Otieno V, dkk. Monocyte-to-lymphocyte ratio is associated with tuberculosis disease and declines with anti-TB treatment in HIV-infected children. J Acquir Immune Defic Syndr. 2019;80(2):174–81.

Janols H, Bredberg A, Thuvesson I, Janciauskiene S, Grip O, Wullt M. Lymphocyte and monocyte flow cytometry immunophenotyping as a diagnostic tool in uncharacteristic inflammatory disorders. BMC Infect Dis. 2010;10:205.

Miyahara R, Piyaworawong S, Naranbhai V, Prachamat P, Kriengwatanapong P, Tsuchiya N, dkk. Predicting the risk of pulmonary tuberculosis based on the neutrophil-to-lymphocyte ratio at TB screening in HIV-infected individuals. BMC Infect Dis. 2019;19(1):667.

Naess A, Nilssen SS, Mo R, Eide GE, Sjursen H. Role of neutrophil to lymphocyte and monocyte to lymphocyte ratios in the diagnosis of bacterial infection in patients with fever. Infection. 2017;45(3):299–307.

Lee JY, Jung YW, Jeong I, Joh JS, Sim SY, Choi B, dkk. Immune parameters differentiating active from latent tuberculosis infection in humans. Tuberculosis (Edinb). 2015;95(6):758–63.

Laghari M, Sulaiman SAS, Khan AH, Memon N. A prospective study of socio-demographic, clinical characteristics and treatment outcomes of children with tuberculosis in Sindh, Pakistan. BMC Infect Dis. 2019;19(1):82.

Basu Roy R, Whittaker E, Seddon JA, Kampmann B. Children and Mycobacterium tuberculosis: a review of susceptibility and protection. Lancet Infect Dis. 2019;19(3):e96–108.

Russell CD, Parajuli A, Gale HJ, Bulteel NS, Schuetz P, de Jager CPC, dkk. The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: a systematic review and meta-analysis. J Infect. 2019;78(5):339–48.




DOI: https://doi.org/10.29313/jiks.v3i2.7501

Refbacks

  • There are currently no refbacks.



eISSN: 2656-8438


View My Stats 


Flag Counter

Jurnal Integrasi Kesehatan dan Sains is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

 

  • https://tkjakartatimur.khoiruummah.id/mahjong/
  • https://tkjakartatimur.khoiruummah.id/qris/
  • https://sdsumedang.khoiruummah.id/smahjong/
  • https://sukabumi.khoiruummah.id/sdana/
  • https://acteaweb.org/bet400/
  • https://acteaweb.org/pulsa/
  • https://journal.literasihukum.com/mahjong/
  • https://journal.literasihukum.com/qris/
  • https://bandar168.store/
  • https://www.giathinhphatinterior.com/
  • https://www.okethelabel.com/
  • https://journal.moseskotaneinstitute.com/nas/liga367-pola-rtp/
  • https://my-klasiber.polhas.ac.id/sj/
  • https://international.unitomo.ac.id/wp-content/languages/hl/
  • https://bpm.unitomo.ac.id/wp-content/uploads/yi/
  • https://library.stieppi.ac.id/stam/
  • https://sastrainggris.ipbcirebon.ac.id/slsa/
  • https://prodi.sisteminformasi.global.ac.id/sris/
  • https://jurnal.fpok.upgripnk.ac.id/public/sloto/
  • https://ejournalperawat.poltekkes-kaltim.ac.id/sesmi/
  • https://library.stieppi.ac.id/xthailand/
  • https://sastrainggris.ipbcirebon.ac.id/xmahjong/
  • https://prodi.sisteminformasi.global.ac.id/xpulsa/
  • https://jurnal.fpok.ikippgriptk.ac.id/public/xqris/
  • https://ejournalperawat.poltekkes-kaltim.ac.id/xdana/
  • https://sumateraconnect.or.id
  • https://pt-ads.co.id/
  • https://bandungprecast.com/
  • https://jasaaspalhotmixbandung.my.id/
  • https://tjvs.tu.edu.iq/
  • https://ojs.al-adab-journal.com/
  • https://insightfuljournals.com/
  • https://interaction.id/
  • https://satpolpp.inhilkab.go.id/sthailand/
  • https://satpolpp.inhilkab.go.id/smahjong//
  • https://my-klasiber.polhas.ac.id/xthailand/
  • https://my-klasiber.polhas.ac.id/xmahjong/
  • https://my-klasiber.polhas.ac.id/slqris/
  • https://my-klasiber.polhas.ac.id/schitam/
  • https://satpolpp.inhilkab.go.id/scahitam/
  • https://satpolpp.inhilkab.go.id/slopulsa/
  • https://satpolpp.inhilkab.go.id/sloqris/
  • stmedj.com
  • inmovil.org
  • journal.fisil.ubhara.ac.id
  • https://egyptscholars.org//
  • Slot Thailand
  • Thailand Slot
  • Slot Deposit Pulsa 10k
  • Slot
  • https://egyptscholars.org/slot-thailand/
  • Slot Thailand
  • Thailand Slot/
  • Slot
  • Slot Deposit Pulsa 10k
  • Slot Maxwin
  • https://v2.stieputrabangsa.ac.id/nity/
  • https://siakad-pben.unida-aceh.ac.id/infy/
  • https://ct.pt-sultra.go.id/site/
  • https://ct.pn-probolinggo.go.id/file/
  • https://sipp.pa-bawean.go.id/site/