.png)
_(1).png){kind=logo}
Scoping Review: Efek Murbei Putih terhadap Penurunan Glycemia Rodensia Model Diabetes Melitus
Abstract
Abstrak
Pengobatan farmakologis diabetes melitus tipe 2 memiliki beberapa hambatan menjalaninya, seperti pengobatan berlangsung seumur hidup dan beragam efek samping. Salah satu pengobatan alternatif, yaitu ekstrak daun murbei putih. Tujuan penelitian ini untuk menilai efek murbei putih terhadap penurunan glycemia pada rodensia model diabetes melitus tipe 2. Penelitian ini menggunakan metode scoping review. Database yang digunakan, yaitu ScienceDirect, Ovid Clinical Edge, dan Google Scholar dengan kata kunci tertentu pada jurnal 2016-2021. Jumlah jurnal yang didapat, yaitu 5598 kemudian di screening dengan PICOS hingga didapatkan lima jurnal. Jurnal dengan kriteria eligible berdasarkan critical appraisal menggunakan instrumen arrive 2.0, yaitu sebanyak lima jurnal. Desain penelitian semua artikel, yaitu true experimental, dengan menggunakan rodensia model diabetes melitus tipe 2. Intervensi yang diberikan adalah dengan berbagai sediaan daun murbei. Pengukuran pada jurnal terpilih, yaitu dengan One Touch Basic blood glucose monitoring system dan kolorimetri dengan Reactivos GPL kits. Hasil dari semua jurnal menunjukkan penurunan gula darah baik gula darah puasa, gula darah sewaktu, atau gula darah intraperitoneal. Proses yang terlibat dalam penurunan gula darah pada penelitian ini, yaitu dengan peningkatan ekspresi GLUT2 dan GLUT4, penurunan absorpsi glukosa di usus dan proses inflamasi, serta mempertahankan massa sel-β pankreas.
Abstract
Treatment of type 2 diabetes mellitus has several obstacles in carrying it out, including lifelong treatment, various of side effects. One of the alternative treatments is white mulberry leaf extract. The purpose of this study was to assess the effect of white mulberry on reducing blood glucose in type 2 diabetes mellitus. This study used a scoping review method. The databases used are ScienceDirect, Ovid Clinical Edge and Google Scholar with the certain keyword taken from 2016–2021. The number of journals obtained was 5598 then screening with PICOS until it is obtained five journals. Journals appropriate with eligible criteria based on critical appraisal using arrive 2.0 instrument, which are five journals. The research design study of all articles is true experimental, using a type 2 diabetes mellitus rodentia . Then intervention provided was with various forms of mulberry leaf. Measurement in the selected articles have various methods such as One Touch Basic blood glucose monitoring system and colorimetry with Reactivos GPL kits. The results of the three journals showed a decrease in fasting blood glucose, one journal showed a decrease in random blood glucose, and one article showed a decrease intraperitoneal blood sugar. The processes involved in lowering blood glucose in this study, by increase serum adiponectin, increase expression of GLUT2 and GLUT4, decrease absorption in the intestine and inflammatory process, and maintain the mass of pancreatic β-cell.
Keywords
Full Text:
PDFReferences
Williams R , Colagiuri S, Almutairi R D. IDF DIABETES ATLAS. Ninth. Suvi Karuranga, Belma Malanda, Pouya Saeedi PS, editor. Brussels: International Diabetes Federation; 2019. 4–77 p.
Kalin MF, Goncalves M, John-Kalarickal J, Fonseca V. Pathogenesis of type 2 diabetes mellitus. Princ Diabetes Mellit Third Ed. 2017;267–77.
DeFronzo RA, Eldor R, Bdul-Ghani MA. Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes. Diabetes Care. 2013;36(SUPPL.2).
Soelistijo SA, Lindarto D, Decroli D. Pedoman pengelolaan dan pencegahan diabetes melitus tipe 2 dewasa di Indonesia 2019. Perkumpulan Endokrinol Indones. 2019;1–117.
Santhanakrishnan I, Lakshminarayanan S, Kar SS. Factors affecting compliance to management of diabetes in Urban Health Center of a tertiary care teaching hospital of south India. J Nat Sci Biol Med. 2014;5(2):365–8.
Prabhakar PK, Doble M. Mechanism of action of natural products used in the treatment of diabetes mellitus. Vol. 17, Chinese Journal of Integrative Medicine. 2011. p. 563–74.
Margaret Chan. Global Report on Diabetes. Isbn. 2016;978:6–86.
Yusni, Akbar IB, Rezania, Fahlevi R. Penurunan Kadar Gula Darah Akibat Pemberian Ekstrak Manggis (Garcinia mangostana) dan Tomat ( Lycopersicum esculentum Mill ) pada Tikus Diabetes. J Glob Med Heal Commun. 2017;5(1):57–63.
Engwerda EEC, Tack CJ, De Galan BE. Needle-free jet injection of rapid-acting insulin improves early postprandial glucose control in patients with diabetes. Diabetes Care. 2013;36(11):3436–41.
Zafar MS, Muhammad F, Javed I, Akhtar M, Khaliq T, Aslam B, et al. White mulberry (Morus alba): A brief phytochemical and pharmacological evaluations account. Int J Agric Biol. 2013;15(3):612–20.
He X, Fang J, Ruan Y, Wang X, Sun Y, Wu N, et al. Structures, bioactivities and future prospective of polysaccharides from Morus alba (white mulberry): A review. Food Chem. 2018;245(October 2017):899–910.
Mena P, Sánchez-Salcedo EM, Tassotti M, Martínez JJ, Hernández F, Del Rio D. Phytochemical evaluation of eight white (Morus alba L.) and black (Morus nigra L.) mulberry clones grown in Spain based on UHPLC-ESI-MSn metabolomic profiles. Food Res Int. 2016 Nov 1;89:1116–22.
Chan EWC, Lye PY, Wong SK. Phytochemistry, pharmacology, and clinical trials of Morus alba. Vol. 14, Chinese Journal of Natural Medicines. Chinese Journal of Natural Medicines Editorial Board; 2016. p. 17–30.
Kadam RA, Dhumal ND, Khyade VB. The Mulberry, Morus alba (L.): The Medicinal Herbal Source for Human Health. Int J Curr Microbiol Appl Sci. 2019;8(04):2941–64.
Badgujar SB, Patel V V., Bandivdekar AH, Mahajan RT. Traditional uses, phytochemistry and pharmacology of Ficus carica: A review. Pharm Biol. 2014;52(11):1487–503.
Ramappa VK, Srivastava D, Singh P, Kumar U, Singh V. Mulberry 1-deoxynojirimycin (DNJ): an exemplary compound for therapeutics. J Hortic Sci Biotechnol. 2020;95(6):679–86.
Wilson RD, Islam MDS. Effects of white mulberry (Morus alba) leaf tea investigated in a type 2 diabetes model of rats. Acta Pol Pharm - Drug Res. 2015;72(1):153–60.
Sahromi. Konservasi ex situ Famili Moraceae di Kebun Raya Bogor, Jawa Barat. Pros Sem Nas Masy Biodiv Indon. 2020;6(1):505–11.
Guangcui Xu YZ. Type 2 Diabetes Mellitus- Disease, Diagnosis and Treatment. J Diabetes Metab. 2015;06(05).
Chaudhary N, Tyagi N. Diabetes mellitus: An Overview. Int J Res Dev Pharm Life Sci. 2018;7(4):3030–3.
Kuai M, Li Y, Sun X, Ma Z, Lin C, Jing Y, et al. A novel formula Sang-Tong-Jian improves glycometabolism and ameliorates insulin resistance by activating PI3K/AKT pathway in type 2 diabetic KKAy mice. Biomed Pharmacother. 2016 Dec 1;84:1585–94.
Metwally FM, Rashad H, Mahmoud AA. Morus alba L. Diminishes visceral adiposity, insulin resistance, behavioral alterations via regulation of gene expression of leptin, resistin and adiponectin in rats fed a high-cholesterol diet. Physiol Behav. 2019 Mar 15;201:1–11.
He X, Li H, Gao R, Zhang C, Liang F, Sheng Y, et al. Mulberry leaf aqueous extract ameliorates blood glucose and enhances energy expenditure in obese C57BL/6J mice. J Funct Foods. 2019 Dec 1;63.
Suthamwong P, Minami M, Okada T, Shiwaku N, Uesugi M, Yokode M, et al. Administration of mulberry leaves maintains pancreatic β-cell mass in obese/type 2 diabetes mellitus mouse model. BMC Complement Med Ther [Internet]. 2020 Dec 6 [cited 2021 Feb 24];20(1):136.
Tian S, Wang M, Liu C, Zhao H, Zhao B. Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway. BMC Complement Altern Med [Internet]. 2019 Dec 21 [cited 2021 Feb 24];19(1):326.
DOI: https://doi.org/10.29313/jiks.v4i1.9423
Refbacks
- There are currently no refbacks.
Jurnal Integrasi Kesehatan dan Sains is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.